Peristaltic pump flow induces amyloid formation

Researchers found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid formation by hen egg white lysozyme, a-synuclein, amyloid b 1-40, and b2-microglobulin. The high shear stresses induced by peristaltic flow likely reflect those that occur the blood and cerebrospinal fluid, suggesting that this factor could promote amyloidosis.